益康唑、咪康唑和克霉唑对细菌有诱变作用吗？

Are econazole, miconazole and clotrimazole mutagenic to bacteria?

作者信息

Voogd C E, van der Stel J J

出版信息

Mutat Res. 1983 May;120(2-3):91-5. doi: 10.1016/0165-7992(83)90148-3.

Abstract

The fungistatic drugs econazole, miconazole and clotrimazole were investigated as to mutagenic properties in the fluctuation test with Klebsiella pneumoniae and Escherichia coli K12 as test organisms and in the plate-incorporation test, with and without metabolic activation, with Salmonella typhimurium strains TA98 and TA100. No mutagenic activity of the 3 compounds on these microorganisms was found.

摘要

以肺炎克雷伯菌和大肠杆菌K12作为测试微生物，通过波动试验研究了抑菌药物益康唑、咪康唑和克霉唑的致突变特性；并以鼠伤寒沙门氏菌TA98和TA100菌株，通过平板掺入试验，在有和没有代谢活化的情况下研究了它们的致突变特性。未发现这3种化合物对这些微生物具有致突变活性。