Dräger U C
Nature. 1983;303(5913):169-72. doi: 10.1038/303169a0.
Different classes of intermediate filaments are restricted to particular cell types. For example, neurofilaments are found only in neurones, whereas filaments that contain the protein vimentin, which were found in some cells of mesenchymal origin and some forms of glia, are thought to be absent from mature neurones, and present only transiently in early embryonic neurones. However, evidence is presented here of an exception to that rule in the outer plexiform layer of the mouse retina. Double-labelling with antibodies to neurofilaments and vimentin showed that both types of intermediate filaments coexisted in the axonless horizontal cell of that retinal layer, recalling the previous notion that these cells are glial or intermediate between neuronal and glial (reviewed in ref. 10).
不同类型的中间丝局限于特定的细胞类型。例如，神经丝仅存在于神经元中，而含有波形蛋白的丝，在一些间充质起源的细胞和某些类型的神经胶质细胞中被发现，据认为在成熟神经元中不存在，仅在早期胚胎神经元中短暂存在。然而，本文提供的证据表明，在小鼠视网膜的外网状层中存在该规则的一个例外情况。用抗神经丝和波形蛋白的抗体进行双重标记显示，这两种类型的中间丝共存于该视网膜层无轴突的水平细胞中，这让人想起之前的观点，即这些细胞是神经胶质细胞，或者是介于神经元和神经胶质细胞之间的中间类型（参考文献10中有综述）。
