van Leeuwen F W, Pool C W, Sluiter A A
Neuroscience. 1983;8(2):229-41. doi: 10.1016/0306-4522(83)90062-3.
Opioid peptides were localized in fibres of the rat neural lobe using various immunocytochemical methods at the light- and electron-microscopical level. Leu-enkephalin immunoreactivity was present in beaded fibres distributed throughout the neural lobe. These fibres surround the neurohypophyseal glial cells (pituicytes) and make synaptoid contacts upon their soma and processes. The reaction product was localized both in dense-core vesicles of about 100 nm in diameter and diffusely spread over the cytoplasm. No arguments in support of the co-existence of enkephalins and the neurohypophyseal hormones vasopressin and oxytocin in the same terminal were found. It is suggested that pituicytes might mediate the inhibitory effect of opiod peptides on vasopressin and oxytocin release from the neural lobe.
利用各种免疫细胞化学方法，在光镜和电镜水平上对大鼠神经叶纤维中的阿片肽进行了定位。亮脑啡肽免疫反应性存在于分布于整个神经叶的串珠状纤维中。这些纤维围绕着神经垂体神经胶质细胞（垂体细胞），并在其胞体和突起上形成类突触接触。反应产物定位于直径约100nm的致密核心囊泡中，并在细胞质中弥漫分布。未发现支持脑啡肽与神经垂体激素血管加压素和催产素在同一终末共存的证据。有人提出，垂体细胞可能介导阿片肽对神经叶中血管加压素和催产素释放的抑制作用。
