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组胺对脊椎动物白细胞迁移试验的影响。II. 白细胞抑制因子——产生抑制剂（LIF-PI）缺乏种属特异性的研究。

Effect of histamine on leukocyte migration tests in vertebrates. II. Study of the lack of species specificity of leukocyte inhibiting factor--production inhibitor (LIF-PI).

作者信息

Rigal D, Monier J C, Mohanna K

出版信息

Thymus. 1983;5(1):53-7.

PMID:6342215
Abstract

Immune regulatory effects of histamine are now well established. We have previously demonstrated that human T lymphocytes having histamine receptors, produce a soluble factor inhibiting the production of LIF. In this present paper we have shown that production and function of this factor is not species specific. Indeed the leukocyte inhibiting factor-production inhibitor (LIF-PI) produced by human, guinea pig or dog lymphocytes inhibits the production of LIF by human, guinea pig and murine lymphocytes to a similar extent. This property allows for easier testing of LIF-PI particularly from human subjects.

摘要

组胺的免疫调节作用现已得到充分证实。我们之前已经证明，具有组胺受体的人类T淋巴细胞会产生一种可溶性因子，抑制白血病抑制因子（LIF）的产生。在本论文中，我们表明该因子的产生和功能并非物种特异性的。实际上，人类、豚鼠或犬类淋巴细胞产生的白细胞抑制因子产生抑制剂（LIF-PI）对人类、豚鼠和鼠类淋巴细胞产生LIF的抑制程度相似。这一特性使得对LIF-PI进行检测更加容易，尤其是对人类受试者的检测。

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Effect of histamine on leukocyte migration tests in vertebrates. II. Study of the lack of species specificity of leukocyte inhibiting factor--production inhibitor (LIF-PI).组胺对脊椎动物白细胞迁移试验的影响。II. 白细胞抑制因子——产生抑制剂（LIF-PI）缺乏种属特异性的研究。
Thymus. 1983;5(1):53-7.
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