Wurtz T, Jockusch H
Mol Gen Genet. 1978 Feb 27;159(3):249-57. doi: 10.1007/BF00268261.
Mutants of Mucor mucedo minus strain that are affected in their trisporic acid (TA) mediated zygophore formation have been isolated. We have found mutants with cold sensitive (cs), with temperature sensitive (ts) and without zygophore formation as well as mutants with unstable zygophores (Zst-). From the appearence of certain pleiotropic phenotypes we deduce a one-dimensional sequence of states of competence of the mycelium to form different organs. TA appears to be a growth substance for zygophores acting on one transient state of competence. The fact that all isolates with lowered response to TA also have a lowered response to the mating type specific TA-precursor P strongly suggests that P has to be converted into TA before inducing zygophore growth. Furthermore, one mutant with lowered sensitivity to TA exhibits an excess zygophore formation in the presence of high TA-concentrations, while high concentrations of P cause a depressed zygophore formation (Fig. 6). Our interpretation of this behaviour is that P acts as an antagonist to TA in the regulation of zygophore growth.
已分离出在其三孢酸（TA）介导的接合孢子形成过程中受到影响的少根根霉突变体。我们发现了具有冷敏感（cs）、温度敏感（ts）且不形成接合孢子的突变体，以及具有不稳定接合孢子（Zst-）的突变体。从某些多效性表型的出现，我们推断出菌丝体形成不同器官的一维能力状态序列。TA似乎是一种作用于一种短暂能力状态的接合孢子生长物质。所有对TA反应降低的分离株对交配型特异性TA前体P的反应也降低，这一事实强烈表明P在诱导接合孢子生长之前必须转化为TA。此外，一个对TA敏感性降低的突变体在高TA浓度下表现出过量的接合孢子形成，而高浓度的P则导致接合孢子形成受抑制（图6）。我们对这种行为的解释是，P在接合孢子生长的调节中作为TA的拮抗剂起作用。
