Kawata M, Hashimoto K, Takahara J, Sano Y
Cell Tissue Res. 1983;230(2):247-58. doi: 10.1007/BF00213803.
Conspicuous differences in the distributional pattern of nerve fibers containing corticotropin-releasing factor (CRF) or posterior lobe hormones, respectively, were shown in the median eminence of the adult male rat by means of immunoperoxidase histochemistry, with the use of anti-CRF, anti-oxytocin, and anti-vasopressin sera. In the rostral and central divisions of the median eminence, a high concentration of CRF-immunoreactive nerve fibers was found in the median portion of the external layer; these fibers terminated on the capillary loops of the hypophysial portal system. In the caudal division of the median eminence, the CRF-immunoreactive nerve fibers were located in the median to paramedian portions of the external layer. Numerous oxytocin- and vasopressin-immunoreactive nerve fibers were observed evenly distributed throughout the internal layer of the median eminence. In the external layer, a small number of the oxytocin- and vasopressin-containing nerve fibers was found around the capillary loops, particularly in the median to paramedian portions. The distributional patterns of the CRF and the posterior lobe hormones in the hypothalamo-hypophysial system and their functional interrelationship are discussed.
通过免疫过氧化物酶组织化学方法，使用抗促肾上腺皮质激素释放因子（CRF）、抗催产素和抗血管加压素血清，在成年雄性大鼠的正中隆起部位分别显示出含有促肾上腺皮质激素释放因子（CRF）或后叶激素的神经纤维分布模式的显著差异。在正中隆起的头侧和中央部分，在外层的中间部分发现高浓度的CRF免疫反应性神经纤维；这些纤维终止于垂体门脉系统的毛细血管袢上。在正中隆起的尾侧部分，CRF免疫反应性神经纤维位于外层的中间至旁中间部分。观察到大量催产素和血管加压素免疫反应性神经纤维均匀分布于正中隆起的内层。在外层，在毛细血管袢周围发现少量含催产素和血管加压素的神经纤维，特别是在中间至旁中间部分。文中讨论了CRF和后叶激素在下丘脑 - 垂体系统中的分布模式及其功能相互关系。
