Lacombe C, Nibbelink M
Diabete Metab. 1983 Mar;9(1):35-41.
The influence of insulin therapy on changes in the lipoprotein profile induced by a semi-synthetic saturated-fat diet was studied in the rabbit. Hypercholesterolemia, observed after two months diet, corresponded to an increase in all lipoprotein fractions as well as an enrichment in cholesterol esters of VLDL and LDL. Treatment with insulin had only a slight effect on the increase in the lipoproteins, but completely prevented the appearance of abnormal LDL. Changes in the lipoprotein profile were markedly aggravated, without an additional increase in plasma cholesterol, when the semi-synthetic diet was continued for six months. All lipoprotein fractions showed increases in cholesterol esters and in free cholesterol at the expense of triglycerides and proteins. The animals receiving the semi-synthetic diet and treated with insulin showed decreased glucose tolerance but no additional modifications in the lipoprotein profile or in the composition of aortic tissue. Therefore, insulin initially prevents alterations in LDL, induced by the semi-synthetic diet, prevention which is not maintained in the long term.
在兔子身上研究了胰岛素治疗对由半合成饱和脂肪饮食引起的脂蛋白谱变化的影响。饮食两个月后观察到的高胆固醇血症，对应于所有脂蛋白组分的增加以及极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）中胆固醇酯的富集。胰岛素治疗对脂蛋白的增加仅有轻微影响，但完全阻止了异常LDL的出现。当半合成饮食持续六个月时，脂蛋白谱的变化明显加剧，而血浆胆固醇没有进一步升高。所有脂蛋白组分的胆固醇酯和游离胆固醇增加，同时甘油三酯和蛋白质减少。接受半合成饮食并接受胰岛素治疗的动物显示糖耐量降低，但脂蛋白谱或主动脉组织成分没有其他改变。因此，胰岛素最初可预防半合成饮食诱导的LDL改变，但这种预防作用在长期内无法维持。
