Candy D C, Leung T S, Marshall W C, Harries J T
Gut. 1983 Jun;24(6):538-41. doi: 10.1136/gut.24.6.538.
Mucosal adhesion of bacteria has been studied in eight infants with protracted diarrhoea and malnutrition, using a buccal epithelial cell technique. A known non-adhesive strain of Escherichia coli (O1:K1:H7) adhered to a significantly greater (p less than 0.001) proportion of buccal epithelial cells from patients with protracted diarrhoea, compared with children with acute diarrhoea, healthy infants, and healthy adults. Also, Enterobacteria isolated from the jejunum or stools of patients with protracted diarrhoea adhered to far greater numbers of their own buccal epithelial cells compared with healthy adults. These results suggest that bacterial adhesion may play an important role in the pathogenesis of protracted diarrhoea.
采用颊黏膜上皮细胞技术,对8例迁延性腹泻伴营养不良的婴儿的细菌黏膜黏附情况进行了研究。与急性腹泻儿童、健康婴儿及健康成人相比,已知的非黏附性大肠杆菌菌株(O1:K1:H7)黏附于迁延性腹泻患者颊黏膜上皮细胞的比例显著更高(p<0.001)。此外,从迁延性腹泻患者空肠或粪便中分离出的肠杆菌黏附于自身颊黏膜上皮细胞的数量,与健康成人相比要多得多。这些结果表明,细菌黏附可能在迁延性腹泻的发病机制中起重要作用。