Burke D A, Axon A T
J Clin Pathol. 1987 Jul;40(7):782-6. doi: 10.1136/jcp.40.7.782.
A quantitative assessment of the mannose resistant, adhesive property of Escherichia coli from patients with ulcerative colitis and from controls was made using a buccal epithelial cell adhesion assay, which also permitted assessment of adhesion to cells from other host sources. E coli from patients with ulcerative colitis adhered to buccal epithelial cells to a greater extent than those obtained from controls (p less than 0.0001), but did not show an increased affinity for the buccal epithelial cell of their host, compared with those obtained from other sources. The mannose resistant adhesive property of E coli raises the possibility that it has a role in the pathogenesis of ulcerative colitis.
采用颊黏膜上皮细胞黏附试验,对溃疡性结肠炎患者及对照者体内大肠杆菌的甘露糖抗性黏附特性进行了定量评估,该试验还可用于评估大肠杆菌对其他宿主来源细胞的黏附情况。与对照者体内分离出的大肠杆菌相比,溃疡性结肠炎患者体内的大肠杆菌对颊黏膜上皮细胞的黏附程度更高(p<0.0001),但与从其他来源分离出的大肠杆菌相比,对其宿主的颊黏膜上皮细胞并未表现出更高的亲和力。大肠杆菌的甘露糖抗性黏附特性提示其可能在溃疡性结肠炎的发病机制中发挥作用。