Hollingdale M R, Leland P, Leef J L, Beaudoin R L
J Parasitol. 1983 Apr;69(2):346-52.
Plasmodium berghei sporozoites successfully entered and developed into exoerythrocytic schizonts in a variety of cell types cultured in vitro, but segmentation and release of merozoites was only observed in human embryonic lung cells. Exoerythrocytic development was generally not influenced by the culture medium, and NCTC-135 was used routinely. In vitro infectivity of P. berghei sporozoites was unaffected by the serum type used for isolation.
伯氏疟原虫子孢子能够成功进入多种体外培养的细胞类型并发育成红细胞外期裂殖体，但仅在人胚肺细胞中观察到裂殖子的分裂和释放。红细胞外期发育一般不受培养基的影响，常规使用的是NCTC - 135培养基。用于分离的血清类型不影响伯氏疟原虫子孢子的体外感染性。
