Hassan S, Pickles H
Prostaglandins Leukot Med. 1983 Apr;10(4):449-54. doi: 10.1016/0262-1746(83)90057-4.
When epoprostenol (prostacyclin, PGI2) is given by infusion to man, cardiac output is increased, and it appears that the gastrointestinal tract may receive a disproportionate share of this. We have used the clearance of indocyanine green dye to estimate liver blood flow in 8 healthy subjects. During an infusion of PGI2 at a dose of 5 ng/kg/min, apparent liver blood flow increased from 925 +/- 220 ml/min (Mean +/- s.d) to 1320 +/- 453 ml/min, an average increase of 41.1%. Significant changes in heart rate, headache, facial flushing, systolic blood pressure, and pulse pressure were noticed. We suggest that endogenous epoprostenol (PGI2) may be of importance in the physiological regulation of liver blood flow in man. As this dose of epoprostenol could be tolerated readily, epoprostenol therapy could prove a therapeutic advance in some liver disorders, particularly liver transplantation, and possibly in the therapy of certain drug overdoses.
当向人体输注依前列醇（前列环素，PGI2）时，心输出量增加，而且胃肠道似乎获得了不成比例的血流量。我们利用吲哚菁绿染料清除率来估计8名健康受试者的肝血流量。在以5 ng/kg/min的剂量输注PGI2期间，表观肝血流量从925±220 ml/min（平均值±标准差）增加至1320±453 ml/min，平均增加41.1%。注意到心率、头痛、面部潮红、收缩压和脉压有显著变化。我们认为内源性依前列醇（PGI2）可能在人体肝血流量的生理调节中起重要作用。由于该剂量的依前列醇易于耐受，依前列醇疗法可能在某些肝脏疾病，特别是肝移植中，以及可能在某些药物过量的治疗中成为一种治疗进展。
