Pickles H, Brown M M, Thomas M, Hewazy A H, Redmond S, Zilkha E, Marshall J
J Neurol Neurosurg Psychiatry. 1984 Jan;47(1):51-5. doi: 10.1136/jnnp.47.1.51.
Cerebral blood flow (CBF) has been measured using a non-invasive Xenon133 clearance technique in six normal subjects after 2 days pretreatment with oral indomethacin at a dose of 100 mg/day. The results were compared with placebo given in a double blind balanced cross-over design. Indomethacin was found to result in a reduction in resting CBF of about 25% but the reactivity of the cerebrovascular circulation to carbon dioxide was preserved at normal levels. Infusions of epoprostenol (prostacyclin, PGI2) at a dose of 5 ng/kg/min resulted in a reduction of CBF of about 10% after placebo but no significant change in CBF after indomethacin. The results suggest that prostaglandins are involved in the maintenance of cerebrovascular tone but not in the mechanism of cerebral vasodilation accompanying hypercapnia. The combination of indomethacin and PGI2 has been proposed as a treatment of cerebral artery spasm and the findings suggest that the combination therapy would not be accompanied by undesirable intracerebral steal.
在6名正常受试者中，采用非侵入性氙133清除技术测量脑血流量（CBF），这些受试者接受了为期2天、剂量为100毫克/天的口服吲哚美辛预处理。结果与采用双盲平衡交叉设计给予的安慰剂进行了比较。发现吲哚美辛可使静息脑血流量降低约25%，但脑血管循环对二氧化碳的反应性保持在正常水平。以5纳克/千克/分钟的剂量输注依前列醇（前列环素，PGI2），在给予安慰剂后可使脑血流量降低约10%，但在给予吲哚美辛后脑血流量无显著变化。结果表明，前列腺素参与脑血管张力的维持，但不参与高碳酸血症伴随的脑血管舒张机制。有人提出将吲哚美辛和PGI2联合用于治疗脑动脉痉挛，研究结果表明联合治疗不会伴有不良的脑内窃血现象。
