Flynn F W, Grill H J
Science. 1983 Jul 8;221(4606):188-90. doi: 10.1126/science.6344221.
Insulin administered to rats reliably elicits ingestion of food. To determine whether the neural mechanisms sufficient to control insulin-elicited ingestion are located in or caudal to the forebrain, decerebrate rats were treated with insulin and ingestive responses were measured. Insulin treatment produced hypoglycemia that was comparable, in magnitude and duration, in control and decerebrate rats. Decerebrate and control rats ingested significantly more sucrose solution while hypoglycemic than while normoglycemic. In contrast, insulin did not augment the water consumption of either group. These data indicate that neural systems caudal to the forebrain are sufficient to control ingestive consummatory behavior through the integration of metabolic signals generated by insulin treatment and taste afferent input from the oropharynx.
给大鼠注射胰岛素确实会引发摄食行为。为了确定足以控制胰岛素引发的摄食行为的神经机制是否位于前脑或前脑尾侧，对去大脑大鼠进行胰岛素处理并测量其摄食反应。胰岛素处理导致的低血糖在程度和持续时间上，在对照大鼠和去大脑大鼠中相当。去大脑大鼠和对照大鼠在低血糖时比血糖正常时摄入的蔗糖溶液明显更多。相比之下，胰岛素并未增加两组大鼠的饮水量。这些数据表明，前脑尾侧的神经系统足以通过整合胰岛素处理产生的代谢信号和来自口咽的味觉传入输入来控制摄食终结行为。
