蜕膜细胞的生活史：综述

Life history of decidual cells: a review.

作者信息

Kearns M, Lala P K

出版信息

Am J Reprod Immunol (1980). 1983 Mar;3(2):78-82. doi: 10.1111/j.1600-0897.1983.tb00219.x.

DOI:10.1111/j.1600-0897.1983.tb00219.x

Abstract

Decidual cells are a distinctive cell population observed in the mammalian endometrium during pregnancy. Their appearance can also be induced with appropriate stimuli in the hormone-primed pseudopregnant uterus. This review deals with their life history, including the dynamic morphological events during the process of decidualization, cytochemical markers for decidual cell reaction, the surface markers and functions of decidual cells, and, finally, the origin and fate of this cell class. The recent discovery of the bone marrow origin of decidual cell precursors adds a new dimension to decidual cell biology. Future studies of steps in the differentiation of the decidual cell lineage await the identification of unique lineage-specific cell--surface of cytoplasmic marker(s); a precise knowledge of decidual cell functions can only be obtained from a discriminating analysis using purified cell populations.

摘要

蜕膜细胞是在妊娠期间哺乳动物子宫内膜中观察到的一种独特细胞群体。在激素预处理的假孕子宫中，给予适当刺激也可诱导其出现。本综述探讨了它们的生命历程，包括蜕膜化过程中的动态形态学事件、蜕膜细胞反应的细胞化学标志物、蜕膜细胞的表面标志物和功能，最后还探讨了这类细胞的起源和命运。最近发现蜕膜细胞前体起源于骨髓，这为蜕膜细胞生物学增添了新的维度。蜕膜细胞谱系分化步骤的未来研究有待鉴定独特的谱系特异性细胞表面或细胞质标志物；只有通过对纯化细胞群体进行鉴别分析，才能精确了解蜕膜细胞的功能。