Robertson R P
Annu Rev Med. 1983;34:1-12. doi: 10.1146/annurev.me.34.020183.000245.
Prostaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glucagon. PGE is postulated to play a role in the pathophysiology of insulin secretion in adult-onset (Type II) diabetes mellitus. Evidence supporting this hypothesis includes the demonstration that PGE inhibits glucose-induced acute insulin responses in normal humans. Moreover, drugs that inhibit synthesis of PGE improve abnormal insulin secretion in human subjects with Type II diabetes mellitus.
E系列前列腺素因其对葡萄糖生成以及胰岛素和胰高血糖素分泌的影响而被认为是葡萄糖稳态的调节因子。据推测，前列腺素E在成年发病型（II型）糖尿病胰岛素分泌的病理生理学中起作用。支持这一假说的证据包括：有证据表明，前列腺素E可抑制正常人葡萄糖诱导的急性胰岛素反应。此外，抑制前列腺素E合成的药物可改善II型糖尿病患者异常的胰岛素分泌。
