Robertson R P
Diabetes. 1983 Mar;32(3):231-4. doi: 10.2337/diab.32.3.231.
Published information derived from studies of prostaglandins on carbohydrate homeostasis and insulin secretion has been considered somewhat controversial by many investigators. An analysis of the literature published since 1876 suggests that this controversy has its roots in imprecise terminology and overgeneralization of data rather than irreconcilable scientific experiments. The two major sources of confusion have been failure to distinguish glucose-induced acute insulin responses from insulin secretion in general and failure to appreciate that the behavior of indomethacin is not consistent with the effects of other nonsteroidal antiinflammatory drugs (cyclooxygenase inhibitors) on glucose homeostasis and insulin secretion. When acute insulin responses to glucose specifically are examined and data from indomethacin studies are excluded, the available information consistently indicates that prostaglandin E has adverse effects on glucose homeostasis and insulin secretion.
许多研究人员认为，从前列腺素对碳水化合物稳态和胰岛素分泌的研究中得出的已发表信息存在一定争议。对自1876年以来发表的文献进行分析表明，这种争议源于术语不精确和数据过度概括，而非不可调和的科学实验。造成混淆的两个主要原因是未能将葡萄糖诱导的急性胰岛素反应与一般的胰岛素分泌区分开来，以及没有认识到吲哚美辛的作用与其他非甾体抗炎药（环氧化酶抑制剂）对葡萄糖稳态和胰岛素分泌的影响不一致。当专门研究对葡萄糖的急性胰岛素反应并排除吲哚美辛研究的数据时，现有信息一致表明前列腺素E对葡萄糖稳态和胰岛素分泌有不利影响。
