Krell R D, Chakrin L W
Int Arch Allergy Appl Immunol. 1976;51(6):641-55. doi: 10.1159/000231643.
Fragmented lung prepared from dogs cutaneously sensitive to ascaris antigen released histamine and a slow-reacting substance of anaphylaxis-like (SRS-A) material upon antigen challenge. Passive sensitization of fragments with serum obtained from ascaris-sensitive donor dogs enhanced the release of both substances; heating (56 degrees C for 4 h) destroyed the ability of the serum to enhance release. In passively sensitized tissues isoproterenol and papaverine inhibited the release of histamine and SRS-A; propranolol antagonized the effect of isoproterenol. Carbachol enhanced the release of both substances from passively sensitized lung wheras disodium cromoglycate and aminoguanidine were without effect. It is concluded that fragmented canine lung is a useful model for study of immediate-type hypersensitivity reactions.
从对蛔虫抗原皮肤敏感的犬制备的肺碎片在抗原攻击时释放组胺和类过敏反应慢反应物质（SRS-A）。用从对蛔虫敏感的供体犬获得的血清对肺碎片进行被动致敏可增强这两种物质的释放；加热（56℃，4小时）破坏了血清增强释放的能力。在被动致敏组织中，异丙肾上腺素和罂粟碱抑制组胺和SRS-A的释放；普萘洛尔拮抗异丙肾上腺素的作用。卡巴胆碱增强了被动致敏肺中这两种物质的释放，而色甘酸钠和氨基胍则无作用。结论是，犬肺碎片是研究速发型过敏反应的有用模型。
