5,6-二甲基-2-硝基茚满二酮钠对体外过敏反应的影响
The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro.
作者信息
Sharpe T J, Ross J W, Spicer B A
出版信息
Agents Actions. 1978 Apr;8(3):199-202. doi: 10.1007/BF01966603.
PMID:78665
Abstract
A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DSCG as an inhibitor of histamine release by antigen from actively and passively sensitized rat peritoneal cells and rat skin fragments.
摘要
一种硝基茚二酮（BRL 10833）在抑制组胺和过敏反应慢反应物质（SRS - A）从被动致敏的人肺组织中由抗原诱导释放方面，所需浓度与色甘酸钠二钠（DSCG）抑制组胺释放所需浓度相似。作为从主动和被动致敏的大鼠腹膜细胞及大鼠皮肤碎片中抑制抗原诱导组胺释放的抑制剂，BRL 10833比DSCG更有效。
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