Wright J R, Yates A J, Sharma H M, Thibert P
Metabolism. 1983 Jul;32(7 Suppl 1):101-5. doi: 10.1016/s0026-0495(83)80021-3.
A total of 145 BB Wistar diabetic rats, 46 of their nondiabetic siblings, and 43 outbred Wistar rats were autopsied and the frequency of lesions in all organ systems were determined. Common strain-related lesions included pulmonary infections, granulomas, lymphoid hyperplasia, lymphomas, lymphocytopenia, eosinophilia, supradiaphragmatic accessory lobes of the liver, and prostatic atrophy. These suggest some basic strain-related abnormalities of the immune system that were selected by the process of inbreeding. Diabetes-related lesions were insulitis, testicular atrophy, cataracts, hepatic fatty change, pancreatitis, lymphocytic thyroiditis, hypoglycemic brain damage, central pontine myelinolysis, stomach erosions, and idiopathic megacolon. Many of these are sequelae of human juvenile-onset diabetes and support the validity of the BB Wistar rat as an animal model for human diabetes mellitus. The absence of several important sequelae of the human disease (i.e., diabetic nephropathy, atherosclerosis, and severe microangiopathy) suggests a degree of infidelity as a model for human diabetes mellitus. Nonspecific lesions occurring in all three groups of rats included myocardial degeneration and fibrosis, splenic extramedullary hematopoiesis, and chronic progressive glomerulonephropathy.
对总共145只BB系Wistar糖尿病大鼠、46只非糖尿病的同窝大鼠以及43只远交Wistar大鼠进行了尸检，并确定了所有器官系统的损伤频率。常见的品系相关损伤包括肺部感染、肉芽肿、淋巴组织增生、淋巴瘤、淋巴细胞减少、嗜酸性粒细胞增多、肝膈上副叶以及前列腺萎缩。这些表明了一些通过近亲繁殖过程选择出来的与品系相关的免疫系统基本异常。糖尿病相关损伤包括胰岛炎、睾丸萎缩、白内障、肝脂肪变性、胰腺炎、淋巴细胞性甲状腺炎、低血糖性脑损伤、中央桥脑髓鞘溶解、胃糜烂以及特发性巨结肠。其中许多是人类青少年型糖尿病的后遗症，支持了BB系Wistar大鼠作为人类糖尿病动物模型的有效性。该模型缺乏人类疾病的一些重要后遗症（即糖尿病肾病、动脉粥样硬化和严重微血管病变），这表明其作为人类糖尿病模型存在一定程度的失真。三组大鼠中出现的非特异性损伤包括心肌变性和纤维化、脾髓外造血以及慢性进行性肾小球肾炎。
