Wright J, Yates A, Sharma H, Thibert P
J Comp Pathol. 1985 Jan;95(1):7-14. doi: 10.1016/0021-9975(85)90072-6.
Pancreatic histopathology was studied in 121 BBWd, 43 BBWnd, and 33 Wistar rats. Insulitis was the most common inflammatory lesion in both BBW and BBWnd rats. The incidence was inversely associated with age and with duration of diabetes in BBWd rats, but there was no age-related pattern in BBWnd rats. Small end-stage islets were typical of BBWd rats but were not seen in BBWnd rats. Several BBWd rats showed hyperplastic islets months after the onset of diabetes, a pattern that is also seen in a small percentage of human JOD patients. Several non-specific exocrine inflammatory lesions occurred in both BBWd and BBWnd rats: acute and/or chronic pancreatitis, eosinophilic infiltrates, granulomatous lesions and acute and/or chronic interstitial inflammation. Only chronic interstitial inflammation was seen in outbred Wistar rats.
对121只BBWd大鼠、43只BBWnd大鼠和33只Wistar大鼠进行了胰腺组织病理学研究。胰岛炎是BBW和BBWnd大鼠中最常见的炎性病变。在BBWd大鼠中，其发病率与年龄及糖尿病病程呈负相关，但在BBWnd大鼠中不存在与年龄相关的模式。小的终末期胰岛是BBWd大鼠的典型特征，但在BBWnd大鼠中未见。几只BBWd大鼠在糖尿病发病数月后出现胰岛增生，这种模式在一小部分人类青少年发病型糖尿病（JOD）患者中也可见到。BBWd和BBWnd大鼠均出现了几种非特异性外分泌炎性病变：急性和/或慢性胰腺炎、嗜酸性粒细胞浸润、肉芽肿性病变以及急性和/或慢性间质性炎症。在远交系Wistar大鼠中仅见慢性间质性炎症。
