Zhurova M V, Lugovaia N A
Probl Endokrinol (Mosk). 1983 May-Jun;29(3):36-40.
In 130 patients, aged 5 to 60 years, with different hypothyrosis forms (congenital, acquired, postoperative) glucose tolerance was studied. In 17 patients the insular apparatus functional state was investigated. The disturbed glucose tolerance corresponding to that of patients with latent diabetes mellitus prevailed in postoperative hypothyrosis, preceded by severe prolonged decompensated thyrotoxicosis, and in congenital hypothyrosis, which compensation required long-term administration of high doses of thyroid hormones. The flatting type of the glycemic curve occurred at an equal rate in young patients (35 to 40 years) with acquired (34.4 +/- 6%) and postoperative (32.4 +/- 8%) short-term hypothyrosis (1 to 3 years), demonstrating a good effect of the substitution therapy. The study of the insular apparatus functional state has shown, that hyperinsulinemia, resultant of glucose injection, prevails in the majority of patients with the thyroid hypofunction.
对130名年龄在5至60岁、患有不同类型甲状腺功能减退症（先天性、后天性、术后）的患者进行了葡萄糖耐量研究。对17名患者的胰岛功能状态进行了调查。术后甲状腺功能减退症（之前有严重的长期失代偿性甲状腺毒症）以及先天性甲状腺功能减退症（其代偿需要长期大剂量服用甲状腺激素）中，葡萄糖耐量异常与潜在糖尿病患者相似。年轻患者（35至40岁）后天性（34.4±6%）和术后（32.4±8%）短期甲状腺功能减退症（1至3年）中，血糖曲线平坦型出现的比例相同，表明替代疗法效果良好。胰岛功能状态研究表明，大多数甲状腺功能减退症患者在注射葡萄糖后会出现高胰岛素血症。
