Thomas D F, Lambert W G, Williams K L
Ann R Coll Surg Engl. 1983 Jul;65(4):226-9.
A simple technique of wound perfusion with bupivacaine (Marcain) which provides sustained postoperative analgesia is described. No complications nor side effects related to toxicity, hypersensitivity, infection, or impaired wound healing were encountered. Postoperative pain was reduced and analgesic requirements were significantly lower in patients undergoing both intermittent (P less than 0.01) and continuous (P = 0.1) wound perfusion (Student t test). Perfusion with isotonic saline was also found to be effective. This may represent a true therapeutic effect attributable to the removal or dilution of pain mediating substances in the wound.
本文描述了一种用布比卡因（耐乐品）进行伤口灌注的简单技术，该技术可提供持续的术后镇痛效果。未出现与毒性、超敏反应、感染或伤口愈合受损相关的并发症或副作用。接受间歇性（P<0.01）和连续性（P = 0.1）伤口灌注的患者术后疼痛减轻，镇痛需求显著降低（学生t检验）。还发现用等渗盐水灌注也有效。这可能代表了一种真正的治疗效果，归因于伤口中疼痛介质的清除或稀释。
