用局部麻醉溶液直接灌注手术伤口：一种解决术后疼痛的方法？
The direct perfusion of surgical wounds with local anaesthetic solution: an approach to postoperative pain?
作者信息
Thomas D F, Lambert W G, Williams K L
出版信息
Ann R Coll Surg Engl. 1983 Jul;65(4):226-9.
Abstract
A simple technique of wound perfusion with bupivacaine (Marcain) which provides sustained postoperative analgesia is described. No complications nor side effects related to toxicity, hypersensitivity, infection, or impaired wound healing were encountered. Postoperative pain was reduced and analgesic requirements were significantly lower in patients undergoing both intermittent (P less than 0.01) and continuous (P = 0.1) wound perfusion (Student t test). Perfusion with isotonic saline was also found to be effective. This may represent a true therapeutic effect attributable to the removal or dilution of pain mediating substances in the wound.
摘要
本文描述了一种用布比卡因（耐乐品）进行伤口灌注的简单技术，该技术可提供持续的术后镇痛效果。未出现与毒性、超敏反应、感染或伤口愈合受损相关的并发症或副作用。接受间歇性（P<0.01）和连续性（P = 0.1）伤口灌注的患者术后疼痛减轻，镇痛需求显著降低（学生t检验）。还发现用等渗盐水灌注也有效。这可能代表了一种真正的治疗效果，归因于伤口中疼痛介质的清除或稀释。
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本文引用的文献
1
Pain control following upper abdominal operations.上腹部手术后的疼痛控制
AMA Arch Surg. 1951 May;62(5):678-82. doi: 10.1001/archsurg.1951.01250030688009.
2
A method for control of postoperative pain.一种控制术后疼痛的方法。
Surg Gynecol Obstet. 1950 Nov;91(5):524-6.
3
Reduction of post-operative pain.减轻术后疼痛。
Br Med J. 1953 May 2;1(4817):973-4. doi: 10.1136/bmj.1.4817.973.
4
Morphine: controlled trial of different methods of administration for postoperative pain relief.吗啡：不同给药方法用于术后镇痛的对照试验
Br Med J. 1980 Jan 5;280(6206):12-3. doi: 10.1136/bmj.280.6206.12.
5
Postoperative analgesia and lung function: a comparison of morphine with extradural block.术后镇痛与肺功能：吗啡与硬膜外阻滞的比较
Br J Anaesth. 1971 Feb;43(2):144-8. doi: 10.1093/bja/43.2.144.
6
Postoperative analgesia and lung function: a comparison of narcotic analgesic regimens.术后镇痛与肺功能：麻醉性镇痛方案的比较
Br J Anaesth. 1973 Apr;45(4):346-52. doi: 10.1093/bja/45.4.346.
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