Barug D, Samson R A, Kerkenaar A
Arzneimittelforschung. 1983;33(4):528-37.
1-[(4-Biphenylyl)-phenylmethyl]-1H-imidazole (bifonazole, Bay h 4502, Mycospor) preferentially inhibited yeast-hypha conversion in the dimorphic fungus Candida albicans. As observed by phase-contrast and scanning electron microscopy the morphology of C. albicans yeast cells and Torulopsis glabrata cells markedly altered after treatment with bifonazole. Whereas control cells were mostly occurring singly, the bifonazole-treated cells did not separate, resulting in the formation of chains and clusters of interconnected cells. Furthermore, in contrast with control cells bifonazole-treated cells of C. albicans and T. glabrata were almost spherical in shape. Evidence is presented by means of fluorescence microscopy that bifonazole-treated yeast cells of C. albicans frequently lacked septa and often contained irregular deposition of chitin.
1-[(4-联苯基)-苯基甲基]-1H-咪唑（联苯苄唑，拜耳h 4502，霉克舒）优先抑制二态真菌白色念珠菌的酵母-菌丝转化。通过相差显微镜和扫描电子显微镜观察发现，用联苯苄唑处理后，白色念珠菌酵母细胞和光滑球拟酵母细胞的形态发生了显著变化。对照细胞大多单个存在，而经联苯苄唑处理的细胞没有分离，导致形成相互连接的细胞链和细胞簇。此外，与对照细胞相比，经联苯苄唑处理的白色念珠菌和光滑球拟酵母细胞几乎呈球形。荧光显微镜检查表明，经联苯苄唑处理的白色念珠菌酵母细胞常常缺乏隔膜，且经常含有几丁质的不规则沉积。
