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子宫内全身照射后新生小鼠的造血作用

Murine neonate hemopoiesis following in utero total-body irradiation.

作者信息

Weinberg S R

出版信息

Biol Neonate. 1983;43(5-6):272-80. doi: 10.1159/000241655.

DOI:10.1159/000241655
PMID:6347265
Abstract

Irradiation (50-200 rad of cobalt-60 gamma rays) on day 10.5 of gestation in the mouse had the following residual effects on neonate and juvenile hemopoiesis: (a) greater damage observed in the day-15 juvenile than in the day-9 neonate; (b) greater fluctuation of peripheral blood hemogram indices from normal values in the day-15 animal than in the day-9 animal; (c) spleen cellularity affected more than bone marrow cellularity; (d) greater radiation injury reflected by bone marrow hemopoietic progenitor cells (erythroid: BFU-E and CFU-E; granulocyte-macrophage: GM-CFC; megakaryocyte: Meg-CFC), and (e) a more pronounced decrease in medulla- and spleen-erythropoietic activity with each increase in dose of irradiation.

摘要

在小鼠妊娠第10.5天进行照射(50 - 200拉德的钴 - 60γ射线),对新生小鼠和幼年小鼠的造血功能有以下残留影响:(a)在第15天的幼年小鼠中观察到的损伤比第9天的新生小鼠更大;(b)第15天动物外周血细胞计数指标相对于正常值的波动比第9天动物更大;(c)脾脏细胞密度比骨髓细胞密度受影响更大;(d)骨髓造血祖细胞(红系:BFU - E和CFU - E;粒 - 巨噬细胞系:GM - CFC;巨核细胞系:Meg - CFC)反映出更大的辐射损伤,以及(e)随着照射剂量的每次增加,骨髓和脾脏红系造血活性的下降更为明显。

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