实验性肾病综合征中初次抗体反应受损。
Impaired primary antibody response in experimental nephrotic syndrome.
作者信息
Garin E H, Sausville P J, Richard G A
出版信息
Clin Exp Immunol. 1983 Jun;52(3):595-8.
Abstract
The primary antibody response to sheep red blood cells (SRBC) is reduced in rats with aminonucleoside of puromycin (AP) nephrosis, as measured by haemagglutination and IgM antibody forming spleen cells (AFC). Since rats immunized 1 day after AP administration had a normal antibody response, these studies suggest that the impaired immune response in nephrotic rats is not due to a direct effect of AP but that it is secondary to the nephrotic state.
摘要
用血细胞凝集和IgM抗体形成脾细胞（AFC）检测发现，患嘌呤霉素氨基核苷（AP）肾病的大鼠对绵羊红细胞（SRBC）的初次抗体反应降低。由于在给予AP后1天免疫的大鼠具有正常的抗体反应，这些研究表明，肾病大鼠免疫反应受损并非由于AP的直接作用，而是继发于肾病状态。
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