Noël P, Levy V G
Nouv Presse Med. 1978 Feb 4;7(5):351-3.
The association in therapeutic doses of gentamicin and furosemide resulted, in a young patient suffering from post-B virus hepatitis cirrhosis, in renal insufficiency which was spontaneously regressive when the drugs were stopped. Gentamicin, used without furosemide, was not associated with any impairment of renal function. A review of the literature indicates a number of pathogenic hypotheses to explain the increased nephrotoxicity of this drug combination.
在一名患有B型病毒后肝硬化的年轻患者中，庆大霉素与呋塞米的治疗剂量联合使用导致了肾功能不全，在停用药物后肾功能不全自发消退。单独使用庆大霉素时，未出现任何肾功能损害。文献综述表明，有多种致病假说可解释这种药物组合肾毒性增加的原因。
