Sinha A K, Jersey G C, Linscombe V A, Adams R L, Mueller A M, McClintock M L
Fundam Appl Toxicol. 1983 Mar-Apr;3(2):95-8. doi: 10.1016/s0272-0590(83)80062-1.
This report presents the cytogenetic findings in bone marrow cells of rats exposed to styrene vapor. Male and female Sprague-Dawley rats were exposed to 0,600 and 1000 ppm of styrene vapor by inhalation 6 hr per day, 5 days a week, for a period of one yr. Blind scoring of metaphase spreads prepared from bone marrow cells collected at the end of the last exposure revealed that neither the 600 ppm nor the 1000 ppm exposures to styrene vapor produced an incidence of chromosomal anomalies higher than those occurring spontaneously. It is interpreted that styrene is non-clastogenic within the present exposure regimen.
本报告呈现了暴露于苯乙烯蒸汽的大鼠骨髓细胞的细胞遗传学研究结果。将雄性和雌性斯普拉格-道利大鼠每天吸入苯乙烯蒸汽6小时，每周5天，持续1年，暴露浓度分别为0、600和1000 ppm。对最后一次暴露结束时收集的骨髓细胞制备的中期分裂相进行盲法评分，结果显示，暴露于600 ppm和1000 ppm苯乙烯蒸汽下产生的染色体异常发生率均不高于自发出现的异常发生率。据解释，在本暴露方案下，苯乙烯不具有致断裂作用。
