接触苯乙烯和乙醇的中国仓鼠骨髓中的染色体畸变

Chromosomal aberrations in bone marrow of Chinese hamsters exposed to styrene and ethanol.

作者信息

Norppa H, Sorsa M, Vainio H

出版信息

Toxicol Lett. 1980 Mar;5(3-4):241-4. doi: 10.1016/0378-4274(80)90066-1.

Abstract

No significant increase was detected in the number of chromosomally damaged cells in bone marrow of Chinese hamsters after either inhalation exposure to 300 ppm styrene or oral intake of 15% ethanol in drinking water (exposure time 4 days or 3 weeks). In combined exposure, a slight increase of chromosomal aberrations was observed in the group exposed for 4 days (2.0% aberrant cells vs. 0.0% in controls). The group exposed for 3 weeks to combined treatment showed no response (0.3% aberrant cells vs. 0.7% in controls).

摘要

中国仓鼠经吸入300 ppm苯乙烯或经口摄入饮用水中15%乙醇（暴露时间4天或3周）后，未检测到骨髓中染色体受损细胞数量有显著增加。在联合暴露中，暴露4天的组观察到染色体畸变略有增加（异常细胞为2.0%，而对照组为0.0%）。联合处理暴露3周的组无反应（异常细胞为0.3%，而对照组为0.7%）。