Penttilä M, Sorsa M, Vainio H
Toxicol Lett. 1980 Jul;6(2):119-23. doi: 10.1016/0378-4274(80)90178-2.
Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 g/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.
给黑腹果蝇喂食500 ppm苯乙烯24小时，苯乙烯对其性染色体不分离的诱导没有影响。给中国仓鼠（黑线仓鼠）腹腔注射单剂量1.0 g/kg体重的苯乙烯或250 mg/kg体重的主要代谢产物氧化苯乙烯后，在中国仓鼠的骨髓中，未观察到来自染色体片段或整条染色体不分离的微核频率增加。
