修复缺陷型人类细胞系中的脱嘌呤DNA内切酶活性
Apurinic DNA endonuclease activities in repair-deficient human cell lines.
作者信息
Moses R E, Beaudet A L
出版信息
Nucleic Acids Res. 1978 Feb;5(2):463-73. doi: 10.1093/nar/5.2.463.
Abstract
Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.
摘要
几种常染色体隐性疾病与细胞培养中明显的DNA修复缺陷相关。共济失调毛细血管扩张症细胞中报道的切除修复缺陷似乎可能反映了脱嘌呤内切酶活性的缺乏。我们在此报告，来自共济失调毛细血管扩张症、着色性干皮病（互补组D）、科凯恩侏儒症、范可尼贫血和布卢姆综合征患者的细胞系提取物中，脱嘌呤内切酶活性水平正常。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
3
Nigrosin as a dye for differentiating live and dead ascites cells.黑色素作为区分活腹水细胞和死腹水细胞的染料。
Exp Cell Res. 1958 Aug;15(1):112-7. doi: 10.1016/0014-4827(58)90067-3.
4
Paper strip method for assaying gradient fractions containing radioactive macromolecules.用于检测含有放射性大分子的梯度级分的纸条法。
Anal Biochem. 1971 Oct;43(2):427-32. doi: 10.1016/0003-2697(71)90272-7.
5
Endonuclease II of Escherichia coli. Degradation of partially depurinated deoxyribonucleic acid.大肠杆菌的核酸内切酶II。部分脱嘌呤脱氧核糖核酸的降解
Biochemistry. 1971 Dec 21;10(26):4986-93. doi: 10.1021/bi00802a024.
6
The mechanism of replication of phi X174 single-stranded DNA. 3. An enzymic study of the structure of the replicative form II DNA.φX174单链DNA的复制机制。3. 复制型II DNA结构的酶学研究。
J Mol Biol. 1971 Apr 28;57(2):177-99. doi: 10.1016/0022-2836(71)90340-8.
7
Defective DNA repair in Fanconi's anaemia.范科尼贫血中的DNA修复缺陷。
Nature. 1974 Jul 19;250(463):223-5. doi: 10.1038/250223a0.
8
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9
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Can J Biochem. 1972 Nov;50(11):1199-209. doi: 10.1139/o72-163.
10
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