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1
DNA polymerases alpha beta and gamma in inherited diseases affecting DNA repair.影响DNA修复的遗传性疾病中的DNA聚合酶α、β和γ
Nucleic Acids Res. 1978 Jun;5(6):2189-96. doi: 10.1093/nar/5.6.2189.
2
Levels of DNA polymerases alpha, beta, and gamma in control and repair-deficient human diploid fibroblasts 1.对照及修复缺陷型人二倍体成纤维细胞1中DNA聚合酶α、β和γ的水平
Nucleic Acids Res. 1977 Jun;4(6):2029-37. doi: 10.1093/nar/4.6.2029.
3
Genetic effects on the longevity of cultured human fibroblasts. III. Correlations with altered glucose-6-phosphate dehydrogenase.遗传因素对培养的人成纤维细胞寿命的影响。III. 与葡萄糖-6-磷酸脱氢酶改变的相关性
Gerontology. 1983;29(2):89-96. doi: 10.1159/000213098.
4
[Chromosome instability syndromes].[染色体不稳定综合征]
Sem Hop. 1983 Dec 1;59(44):3065-79.
5
Levels of DNA polymerase-alpha and beta in normal and xeroderma pigmentosum fibroblasts.正常及着色性干皮病成纤维细胞中DNA聚合酶α和β的水平
Nucleic Acids Res. 1977 Jan;4(1):141-8. doi: 10.1093/nar/4.1.141.
6
Erythrocyte superoxide dismutase in ataxia telangiectasia and Fanconi's anaemia.共济失调毛细血管扩张症和范科尼贫血中的红细胞超氧化物歧化酶
Lancet. 1978 Dec 9;2(8102):1260-1. doi: 10.1016/s0140-6736(78)92139-6.
7
Apurinic DNA endonuclease activities in repair-deficient human cell lines.修复缺陷型人类细胞系中的脱嘌呤DNA内切酶活性
Nucleic Acids Res. 1978 Feb;5(2):463-73. doi: 10.1093/nar/5.2.463.
8
DNA repair enzymes in ataxia telangiectasia and Bloom's syndrome fibroblasts.共济失调毛细血管扩张症和布卢姆综合征成纤维细胞中的DNA修复酶
Biochim Biophys Acta. 1977 Dec 14;479(4):497-500. doi: 10.1016/0005-2787(77)90042-9.
9
DNA repair and human disease.DNA修复与人类疾病
Acta Med Scand. 1976;200(6):433-9. doi: 10.1111/j.0954-6820.1976.tb08259.x.
10
An enzyme activity in normal and ataxia telangiectasia cell lines which is involved in the repair of gamma-irradiation-induced DNA damage.一种存在于正常细胞系和共济失调毛细血管扩张症细胞系中的酶活性，其参与γ射线诱导的DNA损伤修复。
Biochem J. 1980 Jun 15;188(3):677-82. doi: 10.1042/bj1880677.

引用本文的文献

1
Genetic and biochemical studies with ataxia telangiectasia. A review.共济失调毛细血管扩张症的遗传学和生物化学研究。综述。
Hum Genet. 1981;59(1):1-9. doi: 10.1007/BF00278846.
2
Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.共济失调毛细血管扩张症：一种人类遗传性电离辐射敏感障碍。潜在生化缺陷阐释的进展。
Hum Genet. 1987 Mar;75(3):197-208. doi: 10.1007/BF00281059.
3
Altered cellular response to UV irradiation in a patient affected by premature ageing.一名早衰患者对紫外线照射的细胞反应改变。
Hum Genet. 1986 Jul;73(3):189-92. doi: 10.1007/BF00401225.
4
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients.来自正常供体和布卢姆综合征患者的人类细胞系中的DNA连接酶活性。
Nucleic Acids Res. 1989 Apr 25;17(8):3091-106. doi: 10.1093/nar/17.8.3091.
5
DNA polymerase alpha, beta and gamma activities in ultraviolet irradiated CV-1 monkey cells.紫外线照射的CV-1猴细胞中的DNA聚合酶α、β和γ活性
Nucleic Acids Res. 1979 Apr;6(4):1591-605. doi: 10.1093/nar/6.4.1591.

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Defective repair replication of DNA in xeroderma pigmentosum.着色性干皮病中DNA修复复制缺陷。
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DNA repair in human progeroid cells.人类早衰细胞中的DNA修复
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Defective excision repair of gamma-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts.人类（共济失调毛细血管扩张症）成纤维细胞中γ射线损伤DNA的切除修复缺陷。
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Incorporation of (3H)thymidine stimulated by ultraviolet radiation into human fibroblast cultures.紫外线辐射刺激下（3H）胸腺嘧啶核苷掺入人成纤维细胞培养物中。
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Repair of mitomycin C damage to DNA in mammalian cells and its impairment in Fanconi's anemia cells.哺乳动物细胞中丝裂霉素C对DNA损伤的修复及其在范科尼贫血细胞中的损伤情况。
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影响DNA修复的遗传性疾病中的DNA聚合酶α、β和γ

DNA polymerases alpha beta and gamma in inherited diseases affecting DNA repair.

作者信息

Bertazzoni U, Scovassi A I, Stefanini M, Giulotto E, Spadari S, Pedrini A M

出版信息

Nucleic Acids Res. 1978 Jun;5(6):2189-96. doi: 10.1093/nar/5.6.2189.

DOI:10.1093/nar/5.6.2189
PMID:673849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342152/
Abstract

Fibroblasts derived from patients with diseases affecting DNA repair processes, such as Xeroderma Pigmentosum (classical and variant), Fanconi's anemia, Bloom's syndrome, Ataxia Telangiectasica, Progeria and Werner's syndrome, were assayed for the three DNA polymerases. The specific activities of these enzymes were found within the limits observed in normal human fibroblasts. Also the sedimentation properties of the three polymerases were unaltered.

摘要

对来自患有影响DNA修复过程疾病的患者的成纤维细胞进行了三种DNA聚合酶的检测，这些疾病包括色素性干皮病（经典型和变异型）、范可尼贫血、布卢姆综合征、共济失调毛细血管扩张症、早老症和沃纳综合征。发现这些酶的比活性在正常人成纤维细胞所观察到的范围内。这三种聚合酶的沉降特性也未改变。