磷酸克林霉素在骨骼和组织中的渗透情况。
Penetration into bone and tissues of clindamycin phosphate.
作者信息
Baird P, Hughes S, Sullivan M, Willmot I
出版信息
Postgrad Med J. 1978 Feb;54(628):65-7. doi: 10.1136/pgmj.54.628.65.
Abstract
Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean +/- s.e. mean) 5.01 microgram/ml +/- 1.16, N=10; in capsule, 3.29 microgram/ml +/- 0.71, N=12; measured between 1.75 and 3.75 hr after intramuscular and intravenous injections, and in drainage fluid it amounted to 4.61 microgram/ml +/- 0.38, N=11 in 48 hr. Two patients developed diarrhoea which settled within a short period.
摘要
磷酸克林霉素是一种对金黄色葡萄球菌和厌氧菌均有效的抗生素。在13名患者中，采用琼脂扩散法测定了关节置换后其浓度。在骨组织中，浓度为（均值±标准误均值）5.01微克/毫升±1.16，N = 10；在关节囊中，为3.29微克/毫升±0.71，N = 12；在肌肉注射和静脉注射后1.75至3.75小时测定，在引流液中48小时内浓度达4.61微克/毫升±0.38，N = 11。两名患者出现腹泻，但在短时间内缓解。
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本文引用的文献
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2
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Arthritis Rheum. 1969 Dec;12(6):627-35. doi: 10.1002/art.1780120610.
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