Sato K, Abe K, Seino M, Yasujima M, Chiba S, Sato M, Haruyama T, Hiwatari M, Goto T, Tajima J, Tanno M, Yoshinaga K
Prostaglandins Leukot Med. 1983 Jun;11(2):189-97. doi: 10.1016/0262-1746(83)90019-7.
To ascertain whether renal prostaglandin (PG) E synthesis is decreased in patients with essential hypertension (EH), urinary PGE excretion (UPGEV) was measured in 47 normal females and 62 female patients with EH. In order to avoid contaminations of urine by seminal fluids, only female subjects were studied. UPGEV was also measured in female patients with renovascular hypertension (RVH) as well as primary aldosteronism (PA) or idiopathic hyperaldosteronism (IHA). As a whole, UPGEV was lower in patients with EH (226.9 +/- 13.7 ng/day) than that in normal females (317.3 +/- 22.1 ng/day, p less than 0.001). Younger patients (15 to 39 years) had significantly lower UPGEV than normal females of corresponding ages. However, there was no significant difference in UPGEV between older patients (over 40 years) with EH and normal females of the same age range. There were no significant differences in UPGEV among patients with low renin EH, normal renin EH, RVH, PA and IHA. We reconfirmed the decrease in UPGEV in patients with EH as compared with normal controls by studying female subjects. Further, it is suggested that renal PGE synthesis is not influenced by the renin-angiotensin system in these hypertensive states.
为确定原发性高血压（EH）患者的肾前列腺素（PG）E合成是否减少，对47名正常女性和62名EH女性患者的尿PGE排泄量（UPGEV）进行了测量。为避免精液污染尿液，仅研究女性受试者。还对肾血管性高血压（RVH）以及原发性醛固酮增多症（PA）或特发性醛固酮增多症（IHA）的女性患者测量了UPGEV。总体而言，EH患者的UPGEV（226.9±13.7 ng/天）低于正常女性（317.3±22.1 ng/天，p<0.001）。年轻患者（15至39岁）的UPGEV明显低于相应年龄的正常女性。然而，年龄较大（40岁以上）的EH患者与同年龄范围的正常女性之间的UPGEV没有显著差异。低肾素EH、正常肾素EH、RVH、PA和IHA患者之间的UPGEV没有显著差异。通过研究女性受试者，我们再次证实了EH患者的UPGEV与正常对照组相比有所降低。此外，提示在这些高血压状态下，肾PGE合成不受肾素-血管紧张素系统的影响。
