Garcia Zozaya J L, Padilla Viloria M, Rodriguez L, Castro A
Res Commun Chem Pathol Pharmacol. 1983 May;40(2):289-99.
In order to observe alterations of the Renin-Angiotensin-Aldosterone (RAA) system in elderly individuals, 40 healthy Venezuelan mestizos (8 men, 32 women) over 60 years of age were examined. These subjects had a normal sodium and potassium diet and were living under normal conditions. Plasma Renin Activity (PRA), urinary and serum aldosterone levels were determined by radioimmunoassay after two hours of ambulation. Values obtained were compared to those of a similar control group under age 60. The study of the RAA system demonstrated a correlation between PRA, serum and urinary aldosterone, and the daily excretion of sodium, even though less significant than in younger subjects. A continuous, gradual descent in these parameters was observed to be related to the advancement of age until approximately age 60, at which time the PRA demonstrated a sudden drop which was not accompanied by a decrease in the level of aldosterone. The most significant changes occur around the sixth decade of life when these hormone levels drop suddenly and the relationship between PRA, urinary and serum aldosterone changes.
为了观察老年人肾素 - 血管紧张素 - 醛固酮（RAA）系统的变化，对40名60岁以上健康的委内瑞拉混血儿（8名男性，32名女性）进行了检查。这些受试者饮食中钠和钾含量正常，生活条件正常。在行走两小时后，通过放射免疫分析法测定血浆肾素活性（PRA）、尿醛固酮和血清醛固酮水平。将获得的值与60岁以下的类似对照组的值进行比较。对RAA系统的研究表明，PRA、血清和尿醛固酮与钠的每日排泄量之间存在相关性，尽管这种相关性不如年轻受试者显著。观察到这些参数持续、逐渐下降与年龄增长有关，直到大约60岁，此时PRA出现突然下降，而醛固酮水平并未随之降低。最显著的变化发生在生命的第六个十年左右，此时这些激素水平突然下降，PRA、尿醛固酮和血清醛固酮之间的关系也发生了变化。
