Schønheyder H, Andersen I, Andersen P
Sabouraudia. 1983 Jun;21(2):149-57.
IgG and IgA serum antibodies to Aspergillus fumigatus were determined in 47 patients with rheumatic disorders, 4 patients with pulmonary aspergillosis associated with rheumatic disease, and in 36 healthy controls. Antibody titres determined by indirect immunofluorescence were comparable in patients with rheumatic diseases and in controls, except for 2 patients with IgG antibody titres within the upper range of patients with aspergillosis. IgG antibody levels to 2 partially purified A. fumigatus antigens (I and VIII), determined by enzyme-linked immunosorbent assay (ELISA), were higher in rheumatic patients than in controls and with antigen VIII the difference reached statistical significance for all subgroups of rheumatic patients. IgA antibody levels by ELISA were also increased in rheumatic patients compared with the control group: IgA levels against antigen I fell within the range of patients with aspergillosis in 7 patients with rheumatic disorders. This suggests that some rheumatic patients are more strongly sensitized to Aspergillus antigens than normal subjects.
对47例风湿性疾病患者、4例与风湿性疾病相关的肺曲霉病患者以及36名健康对照者测定了血清中针对烟曲霉的IgG和IgA抗体。通过间接免疫荧光法测定的抗体滴度在风湿性疾病患者和对照者中相当，但有2例患者的IgG抗体滴度处于曲霉病患者的较高范围内。通过酶联免疫吸附测定（ELISA）测定的针对2种部分纯化的烟曲霉抗原（I和VIII）的IgG抗体水平，风湿性疾病患者高于对照者，且对于抗原VIII，所有风湿性疾病亚组的差异均具有统计学意义。与对照组相比，风湿性疾病患者通过ELISA测定的IgA抗体水平也有所升高：7例风湿性疾病患者中针对抗原I的IgA水平处于曲霉病患者的范围内。这表明一些风湿性疾病患者对曲霉抗原的致敏程度比正常受试者更强。
