Matsukura N, Shirota A, Maruyama K
Gan To Kagaku Ryoho. 1983 Feb;10(2 Pt 2):471-81.
Intestinal metaplasia of the stomach is classified into two types, complete and incomplete, by enzymatical, mucin histochemical and histological differences. Complete type resembles the small intestine while incomplete type does not. But, even complete type differs from the small intestine from the point of cytological observations. Vascular structures of the metaplastic mucosa are different from those in the mucosae of stomach, small and large intestines. Focal intestinal metaplasia can be induced in rats by a gastric carcinogen, N-propyl-N'-nitro-N-nitrosoguanidine or regeneration after ulceration with 0.5 NaOH. There is no solid evidence that intestinal metaplasia is a precancerous change of the stomach. However, the patients with extensive intestinal metaplasia of the stomach belong to the high risk group for the gastric cancer. Therefore, careful follow-up studies are needed for these patients using endoscopy by dye-staining method.
胃的肠化生根据酶学、黏液组织化学和组织学差异分为完全型和不完全型两种类型。完全型类似于小肠，而不完全型则不同。但是，即使是完全型，从细胞学观察的角度来看也与小肠不同。化生黏膜的血管结构与胃、小肠和大肠黏膜的血管结构不同。大鼠可通过胃致癌物N-丙基-N'-硝基-N-亚硝基胍或用0.5%氢氧化钠溃疡后再生诱导局灶性肠化生。没有确凿证据表明肠化生是胃癌的癌前病变。然而，胃广泛肠化生的患者属于胃癌高危人群。因此，需要对这些患者采用内镜染色法进行仔细的随访研究。
