Schmid C, Steiner T, Froesch E R
FEBS Lett. 1983 Sep 5;161(1):117-21. doi: 10.1016/0014-5793(83)80742-x.
Cells prepared from the body walls of chicken embryos were plated in the absence of serum. Insulin-like growth factors (IGFs) barely stimulated cell replication, but preferentially enhanced the differentiation of muscle cells. Myoblast fusion was favoured in the presence of IGF (or insulin). Concomitantly, acetylcholinesterase activity increased. IGF I and IGF II were equipotent and active in low physiological concentrations, in contrast to insulin, which was known for a long time to exert such effects at pharmacological concentrations.
从鸡胚体壁制备的细胞在无血清条件下进行铺板培养。胰岛素样生长因子（IGFs）几乎不刺激细胞复制，但优先增强肌肉细胞的分化。在IGF（或胰岛素）存在的情况下，成肌细胞融合更易发生。同时，乙酰胆碱酯酶活性增加。IGF I和IGF II在低生理浓度下具有同等效力且有活性，这与胰岛素不同，胰岛素长期以来被认为在药理浓度下才发挥此类作用。
