Lind L, Wide L, Sörensen O H, Ljunghall S
Department of Internal Medicine, Uppsala University, Sweden.
J Hum Hypertens. 1989 Apr;3(2):137-40.
In recent years abnormalities of calcium metabolism have been described in human hypertension. In this study, the relationships between indices of calcium metabolism and the renin-aldosterone system were studied in 39 subjects with untreated essential hypertension. No significant associations were found between the major determinants of calcium metabolism (plasma ionised calcium, parathyroid hormone and 1,25(OH)2-vitamin D) and the renin-aldosterone system. Serum magnesium was, however, positively correlated to plasma renin activity (PRA) (r = 0.38, P less than 0.05) while both 24 h urinary excretion of calcium and cAMP were found to be correlated to both PRA and urinary aldosterone in a positive way (r = 0.39-0.42, P less than 0.01 and r = 0.33-0.57, P less than 0.01, respectively). In this study there was no other evidence of any major influence of the renin-aldosterone status on the calcium balance in human hypertension. The urinary leak of calcium might be determined by the action of the renin-aldosterone system.
近年来，人们已发现人类高血压存在钙代谢异常。在本研究中，对39例未经治疗的原发性高血压患者的钙代谢指标与肾素 - 醛固酮系统之间的关系进行了研究。钙代谢的主要决定因素（血浆离子钙、甲状旁腺激素和1,25(OH)₂ - 维生素D）与肾素 - 醛固酮系统之间未发现显著关联。然而，血清镁与血浆肾素活性（PRA）呈正相关（r = 0.38，P < 0.05），同时发现24小时尿钙排泄量和环磷酸腺苷（cAMP）均与PRA和尿醛固酮呈正相关（分别为r = 0.39 - 0.42，P < 0.01和r = 0.33 - 0.57，P < 0.01）。在本研究中，没有其他证据表明肾素 - 醛固酮状态对人类高血压患者的钙平衡有任何重大影响。尿钙泄漏可能由肾素 - 醛固酮系统的作用决定。
