酵母中人工染色体的构建。
Construction of artificial chromosomes in yeast.
作者信息
Murray A W, Szostak J W
出版信息
Nature. 1983;305(5931):189-93. doi: 10.1038/305189a0.
DOI:10.1038/305189a0
PMID:6350893
Abstract
Fifty-five-kilobase long artificial chromosomes containing cloned genes, replicators, centromeres and telomeres have been constructed in yeast. These molecules have many of the properties of natural yeast chromosomes. Centromere function is impaired on short (less than 20 kilobases) artificial chromosomes.
摘要
在酵母中构建了包含克隆基因、复制子、着丝粒和端粒的55千碱基对长的人工染色体。这些分子具有许多天然酵母染色体的特性。短的（小于20千碱基对）人工染色体上着丝粒功能受损。
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