Wang B C, Sundet W D, Hakumäki M O, Goetz K L
Am J Physiol. 1983 Sep;245(3):H399-405. doi: 10.1152/ajpheart.1983.245.3.H399.
We measured plasma arginine vasopressin (AVP) and plasma renin activity (PRA) during continuous hemorrhage in cardiac-denervated and sham-operated conscious dogs. Hemorrhage produced comparable decreases in aortic pressure, cardiac output, stroke volume, pulmonary arterial pressure, and left and right atrial pressures in each group of dogs. After 10 ml blood/kg body wt had been removed, AVP was increased in sham-operated dogs (P less than 0.05) but not in cardiac-denervated dogs. After 20 and 30 ml blood/kg body wt had been removed, AVP was increased in all dogs, but the response was markedly attenuated in cardiac-denervated dogs. Hemorrhage at 10 and 20 ml/kg caused comparable increases in PRA in each group of dogs. However, at 30 ml/kg hemorrhage the increase in PRA was significantly higher in cardiac-denervated dogs than in sham-operated dogs. Our results suggest that cardiac receptors play a dominant role in mediating the release of AVP during hemorrhage in conscious dogs. In contrast, we found no evidence for a dominant role of cardiac receptors in mediating renin secretion during hemorrhage.
我们在心脏去神经支配和假手术的清醒犬持续出血过程中测量了血浆精氨酸血管加压素（AVP）和血浆肾素活性（PRA）。每组犬出血均使主动脉压、心输出量、每搏量、肺动脉压以及左、右心房压出现类似程度的降低。每千克体重失血10ml后，假手术犬的AVP升高（P<0.05），而心脏去神经支配犬则未升高。每千克体重失血20ml和30ml后，所有犬的AVP均升高，但心脏去神经支配犬的反应明显减弱。每千克体重失血10ml和20ml时，每组犬的PRA出现类似程度的升高。然而，每千克体重失血30ml时，心脏去神经支配犬的PRA升高幅度显著高于假手术犬。我们的结果提示，在清醒犬出血期间，心脏感受器在介导AVP释放中起主要作用。相反，我们未发现有证据表明心脏感受器在出血期间介导肾素分泌中起主要作用。
