Rigas B, Levine L
Biochem Biophys Res Commun. 1983 Aug 30;115(1):201-5. doi: 10.1016/0006-291x(83)90989-0.
A circadian rhythm in the concentrations of prostaglandins (PG) E2, PGF2, PGI2 (measured as 6-keto-PGF1 alpha), immunoreactive h hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these compounds in saliva. Under usual sleep-wake cycles a single peak occurred during sleep with maximal levels at 5:00 AM; the amplitude of the peak varied for each product. The rhythm was sleep-dependent and a shift occurred when the sleep-wake cycles were displaced. Basal levels of these eicosanoids were maintained even without sleep.
在人类混合唾液中观察到前列腺素（PG）E2、PGF2、PGI2（以6-酮-PGF1α测量）、免疫反应性h-羟基二十碳四烯酸和免疫反应性含6-硫肽白三烯浓度的昼夜节律。该节律反映了唾液中这些化合物绝对量的变化。在通常的睡眠-觉醒周期下，睡眠期间出现单个峰值，凌晨5:00达到最高水平；每个产物的峰值幅度各不相同。该节律依赖于睡眠，当睡眠-觉醒周期被打乱时会发生变化。即使没有睡眠，这些类花生酸的基础水平也能维持。
