高剂量美法仑与自体骨髓移植治疗晚期恶性黑色素瘤。
Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation.
作者信息
Cornbleet M A, McElwain T J, Kumar P J, Filshie J, Selby P, Carter R L, Hedley D W, Clark M L, Millar J L
出版信息
Br J Cancer. 1983 Sep;48(3):329-34. doi: 10.1038/bjc.1983.196.
Abstract
Twenty-eight patients with advanced life-threatening metastatic malignant melanoma were treated with high dose (140-260 mgm-2) intravenous melphalan and autologous bone marrow. Cyclophosphamide "priming" 300 mgm-2 i.v. was given to 19 patients one week previously and this resulted in clinical but not histological evidence of amelioration of gastrointestinal toxicity. In 11 patients (43%) there was evidence of tumour response to treatment and in 2 patients complete remissions were observed. However in most patients, responses were short-lived and no patient lived longer than 17 months from start of treatment or 24 months from first recorded evidence of distant metastatic disease.
摘要
28例晚期危及生命的转移性恶性黑色素瘤患者接受了高剂量（140 - 260mgm-2）静脉美法仑和自体骨髓治疗。19例患者在一周前接受了300mgm-2静脉注射环磷酰胺“预处理”，这在临床上减轻了胃肠道毒性，但组织学上无明显改善。11例患者（43%）有肿瘤对治疗有反应的证据，2例患者观察到完全缓解。然而，大多数患者的反应是短暂的，从治疗开始没有患者存活超过17个月，或从首次记录远处转移性疾病证据起超过24个月。
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