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1
Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation.高剂量美法仑与自体骨髓移植治疗晚期恶性黑色素瘤。
Br J Cancer. 1983 Sep;48(3):329-34. doi: 10.1038/bjc.1983.196.
2
Treatment of metastatic malignant melanoma with intensive melphalan and autologous bone marrow transplantation.采用大剂量美法仑及自体骨髓移植治疗转移性恶性黑色素瘤。
Cancer Treat Rep. 1985 May;69(5):473-7.
3
Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer.大剂量美法仑化疗及冷冻保存自体骨髓移植治疗难治性癌症。
J Clin Oncol. 1983 Jun;1(6):359-67. doi: 10.1200/JCO.1983.1.6.359.
4
High-dose combination cyclophosphamide, cisplatin, and melphalan with autologous bone marrow support. A clinical and pharmacologic study.高剂量环磷酰胺、顺铂和马法兰联合自体骨髓支持：一项临床与药理学研究。
Cancer Chemother Pharmacol. 1989;23(6):377-83. doi: 10.1007/BF00435840.
5
High dose melphalan and non-cryopreserved autologous bone marrow treatment of malignant melanoma and neuroblastoma.大剂量美法仑与非冷冻保存自体骨髓治疗恶性黑色素瘤和神经母细胞瘤。
Exp Hematol. 1979;7 Suppl 5:360-71.
6
Marrow autotransplantation accelerates haematological recovery in patients with malignant melanoma treated with high-dose melphalan.骨髓自体移植可加速接受大剂量美法仑治疗的恶性黑色素瘤患者的血液学恢复。
Br J Cancer. 1979 Jul;40(1):72-80. doi: 10.1038/bjc.1979.142.
7
Phase II trial of high-dose melphalan and autologous bone marrow transplantation for metastatic colon carcinoma.大剂量美法仑与自体骨髓移植治疗转移性结肠癌的II期试验
J Clin Oncol. 1986 Nov;4(11):1586-91. doi: 10.1200/JCO.1986.4.11.1586.
8
Gut protection by cyclophosphamide "priming" in patients receiving high-dose melphalan--effect of drug scheduling.接受大剂量美法仑治疗的患者中，环磷酰胺“预处理”对肠道的保护作用——给药方案的影响
Cancer Chemother Pharmacol. 1992;30(2):149-51. doi: 10.1007/BF00686408.
9
Conventional dose melphalan is inactive in metastatic melanoma: results of an Eastern Cooperative Oncology Group Study (E1687).常规剂量美法仑对转移性黑色素瘤无效：东部肿瘤协作组研究（E1687）结果
Anticancer Drugs. 1999 Feb;10(2):245-8. doi: 10.1097/00001813-199902000-00014.
10
Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan.在接受大剂量美法仑治疗的患者中，环磷酰胺预处理对骨髓恢复的加速作用。
Lancet. 1978 Nov 4;2(8097):966-8. doi: 10.1016/s0140-6736(78)92529-1.

引用本文的文献

1
The history and future of chemotherapy for melanoma.黑色素瘤化疗的历史与未来
Hematol Oncol Clin North Am. 2009 Jun;23(3):583-97, x. doi: 10.1016/j.hoc.2009.03.006.
2
Stem-cell transplantation for the treatment of advanced solid tumors.干细胞移植治疗晚期实体瘤。
Springer Semin Immunopathol. 2004 Nov;26(1-2):31-56. doi: 10.1007/s00281-004-0160-8. Epub 2004 Sep 11.
3
Cell survival in four ovarian carcinoma xenografts following in vitro exposure to melphalan, cisplatin and cis-diammine-1,1-cyclobutane dicarboxylate platinum II (CBDCA,JM8).体外暴露于美法仑、顺铂和顺二氨-1,1-环丁烷二羧酸铂II（CBDCA，JM8）后四种卵巢癌异种移植瘤中的细胞存活情况。
Cancer Chemother Pharmacol. 1984;13(2):109-13. doi: 10.1007/BF00257125.
4
Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts.维拉帕米和酒精对小鼠纤维肉瘤及人黑色素瘤异种移植瘤的血流、美法仑摄取及细胞毒性的影响。
Br J Cancer. 1986 May;53(5):607-14. doi: 10.1038/bjc.1986.103.
5
Melphalan concentration dependent plasma protein binding in healthy humans and rats.美法仑在健康人类和大鼠体内的血浆蛋白结合呈浓度依赖性。
Eur J Clin Pharmacol. 1987;32(2):179-85. doi: 10.1007/BF00542192.
6
Treatment of advanced neuroblastoma with high-dose melphalan and autologous bone marrow transplantation.大剂量美法仑联合自体骨髓移植治疗晚期神经母细胞瘤
Cancer Chemother Pharmacol. 1986;16(2):165-9. doi: 10.1007/BF00256169.
7
In vitro selective effect of melphalan on human T-cell populations.美法仑对人T细胞群体的体外选择性作用。
Cancer Immunol Immunother. 1985;19(1):53-6. doi: 10.1007/BF00199312.
8
Cyclophosphamide priming reduces intestinal damage in man following high dose melphalan chemotherapy.环磷酰胺预处理可减轻大剂量美法仑化疗后人体的肠道损伤。
Br J Cancer. 1987 May;55(5):531-3. doi: 10.1038/bjc.1987.108.
9
High dose BCNU chemotherapy with autologous bone marrow transplantation and full dose radiotherapy for grade IV astrocytoma.大剂量卡氮芥化疗联合自体骨髓移植及全剂量放疗治疗IV级星形细胞瘤。
Br J Cancer. 1988 Dec;58(6):779-82. doi: 10.1038/bjc.1988.308.
10
Recombinant interleukin-2 (rIL-2) given intrasplenically and intravenously for advanced malignant melanoma. A phase I and II study.重组白细胞介素-2（rIL-2）经脾内和静脉内给药用于晚期恶性黑色素瘤。一项I期和II期研究。
Br J Cancer. 1989 Nov;60(5):770-4. doi: 10.1038/bjc.1989.357.

本文引用的文献

1
DECLINE IN COLONY-FORMING ABILITY OF MARROW CELLS SUBJECTED TO SERIAL TRANSPLANTATION INTO IRRADIATED MICE.连续移植到受照射小鼠体内的骨髓细胞集落形成能力的下降
J Cell Comp Physiol. 1964 Aug;64:23-31. doi: 10.1002/jcp.1030640104.
2
Colony growth and clonogenic cell survival in human melanoma xenografts treated with chemotherapy.化疗治疗的人黑色素瘤异种移植瘤中的集落生长和克隆细胞存活
Br J Cancer. 1980 Sep;42(3):438-47. doi: 10.1038/bjc.1980.256.
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Isolated limb perfusion for malignant melanoma.恶性黑色素瘤的隔离肢体灌注
Practitioner. 1980 Oct;224(1348):1031-6.
4
Treatment of advanced malignant melanoma with high-dose chemotherapy and autologous bone marrow transplantation. Preliminary results--Phase I study.大剂量化疗联合自体骨髓移植治疗晚期恶性黑色素瘤。初步结果——I期研究
Am J Clin Oncol. 1982 Dec;5(6):611-22. doi: 10.1097/00000421-198212000-00007.
5
Chemotherapy of melanoma.黑色素瘤的化疗
Semin Oncol. 1975 Jun;2(2):179-85.
6
Cyclophosphamide pretreatment reduces the toxic effect of high dose melphalan on intestinal epithelium in sheep.环磷酰胺预处理可降低高剂量美法仑对绵羊肠道上皮的毒性作用。
Eur J Cancer (1965). 1978 Nov;14(11):1283-5. doi: 10.1016/0014-2964(78)90236-0.
7
Effect of high-dose melphalan on marrow and intestinal epithelium in mice pretreated with cyclophosphamide.高剂量美法仑对经环磷酰胺预处理的小鼠骨髓和肠上皮的影响。
Br J Cancer. 1978 Jul;38(1):137-42. doi: 10.1038/bjc.1978.173.
8
Nature of the hemopoietic stem cell compartment and its proliferative potential.造血干细胞区室的性质及其增殖潜力。
Blood Cells. 1979 Jun 15;5(2):195-210.
9
Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan.在接受大剂量美法仑治疗的患者中，环磷酰胺预处理对骨髓恢复的加速作用。
Lancet. 1978 Nov 4;2(8097):966-8. doi: 10.1016/s0140-6736(78)92529-1.
10
Organization of haemopoietic stem cells: the generation-age hypothesis.造血干细胞的组织：生成-年龄假说。
Cell Tissue Kinet. 1979 Jan;12(1):17-29. doi: 10.1111/j.1365-2184.1979.tb00110.x.

高剂量美法仑与自体骨髓移植治疗晚期恶性黑色素瘤。

Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation.

作者信息

Cornbleet M A, McElwain T J, Kumar P J, Filshie J, Selby P, Carter R L, Hedley D W, Clark M L, Millar J L

出版信息

Br J Cancer. 1983 Sep;48(3):329-34. doi: 10.1038/bjc.1983.196.

DOI:10.1038/bjc.1983.196
PMID:6351883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2011461/
Abstract

Twenty-eight patients with advanced life-threatening metastatic malignant melanoma were treated with high dose (140-260 mgm-2) intravenous melphalan and autologous bone marrow. Cyclophosphamide "priming" 300 mgm-2 i.v. was given to 19 patients one week previously and this resulted in clinical but not histological evidence of amelioration of gastrointestinal toxicity. In 11 patients (43%) there was evidence of tumour response to treatment and in 2 patients complete remissions were observed. However in most patients, responses were short-lived and no patient lived longer than 17 months from start of treatment or 24 months from first recorded evidence of distant metastatic disease.

摘要

28例晚期危及生命的转移性恶性黑色素瘤患者接受了高剂量（140 - 260mgm-2）静脉美法仑和自体骨髓治疗。19例患者在一周前接受了300mgm-2静脉注射环磷酰胺“预处理”，这在临床上减轻了胃肠道毒性，但组织学上无明显改善。11例患者（43%）有肿瘤对治疗有反应的证据，2例患者观察到完全缓解。然而，大多数患者的反应是短暂的，从治疗开始没有患者存活超过17个月，或从首次记录远处转移性疾病证据起超过24个月。