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在接受大剂量美法仑治疗的患者中，环磷酰胺预处理对骨髓恢复的加速作用。

Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan.

作者信息

Hedley D W, McElwain T J, Millar J L, Gordon M Y

出版信息

Lancet. 1978 Nov 4;2(8097):966-8. doi: 10.1016/s0140-6736(78)92529-1.

DOI:10.1016/s0140-6736(78)92529-1
PMID:81990
Abstract

7 patients with advanced malignant melanoma who were given cyclophosphamide (500 mg intravenously) 7 days before a high dose of melphalan (140 mg/m2) had a more rapid recovery of the peripheral white-cell count than did 4 patients who received melphalan alone. "Priming" by cyclophosphamide might be a practicable means of offsetting the bone-marrow toxicity of some chemotherapy regimens and it may permit higher doses of drugs to be given safely.

摘要

7例晚期恶性黑色素瘤患者在大剂量美法仑（140mg/m²）给药前7天静脉注射环磷酰胺（500mg），其外周白细胞计数的恢复比4例单独接受美法仑治疗的患者更快。环磷酰胺的“预激”可能是抵消某些化疗方案骨髓毒性的一种可行方法，并且可能允许安全地给予更高剂量的药物。

相似文献

1
Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan.在接受大剂量美法仑治疗的患者中，环磷酰胺预处理对骨髓恢复的加速作用。
Lancet. 1978 Nov 4;2(8097):966-8. doi: 10.1016/s0140-6736(78)92529-1.
2
High-dose combination cyclophosphamide, cisplatin, and melphalan with autologous bone marrow support. A clinical and pharmacologic study.高剂量环磷酰胺、顺铂和马法兰联合自体骨髓支持：一项临床与药理学研究。
Cancer Chemother Pharmacol. 1989;23(6):377-83. doi: 10.1007/BF00435840.
3
Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation.高剂量美法仑与自体骨髓移植治疗晚期恶性黑色素瘤。
Br J Cancer. 1983 Sep;48(3):329-34. doi: 10.1038/bjc.1983.196.
4
High-dose cyclophosphamide or melphalan with escalating doses of mitoxantrone and autologous bone marrow transplantation for refractory solid tumors.高剂量环磷酰胺或美法仑联合递增剂量米托蒽醌及自体骨髓移植治疗难治性实体瘤。
Cancer Res. 1989 Aug 15;49(16):4654-8.
5
Marrow autotransplantation accelerates haematological recovery in patients with malignant melanoma treated with high-dose melphalan.骨髓自体移植可加速接受大剂量美法仑治疗的恶性黑色素瘤患者的血液学恢复。
Br J Cancer. 1979 Jul;40(1):72-80. doi: 10.1038/bjc.1979.142.
6
An evaluation of large intermittent intravenous doses of cyclophosphamide (NSC-26271) in the treatment of metastatic malignant melanoma.大剂量间歇性静脉注射环磷酰胺（NSC - 26271）治疗转移性恶性黑色素瘤的评估。
Cancer Chemother Rep. 1970 Oct;54(5):365-7.
7
High-dose melphalan and cyclophosphamide pre-treatment.大剂量美法仑和环磷酰胺预处理。
Lancet. 1978 Dec 16;2(8103):1313-4. doi: 10.1016/s0140-6736(78)92080-9.
8
High-dose combination alkylating agent preparative regimen with autologous bone marrow support: the Dana-Farber Cancer Institute/Beth Israel Hospital experience.高剂量联合烷化剂预处理方案与自体骨髓支持：达纳-法伯癌症研究所/贝斯以色列医院的经验。
Cancer Treat Rep. 1987 Feb;71(2):119-25.
9
Improved priming for mobilization of and optimal timing for harvest of peripheral blood stem cells.改善外周血干细胞动员的预充及最佳采集时机。
J Hematother. 1996 Aug;5(4):399-406. doi: 10.1089/scd.1.1996.5.399.
10
Melphalan plus total body irradiation (MEL-TBI) or cyclophosphamide (MEL-CY) as a conditioning regimen with second autotransplant in responding patients with myeloma is inferior compared to historical controls receiving tandem transplants with melphalan alone.对于反应性骨髓瘤患者，使用美法仑加全身照射（MEL-TBI）或环磷酰胺（MEL-CY）作为预处理方案并进行第二次自体移植，与仅接受美法仑串联移植的历史对照相比效果较差。
Bone Marrow Transplant. 2000 Mar;25(5):483-7. doi: 10.1038/sj.bmt.1702167.

引用本文的文献

1
The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.氧化还原和巯基状态对骨髓的影响：药理干预策略。
Pharmacol Ther. 2011 Feb;129(2):172-84. doi: 10.1016/j.pharmthera.2010.09.008. Epub 2010 Oct 15.
2
The effect of treatment with high dose melphalan, cisplatin or carboplatin on levels of glutathione in plasma, erythrocytes, mononuclear cells and urine.
Cancer Chemother Pharmacol. 1996;37(5):479-85. doi: 10.1007/s002800050415.
3
Improving the therapeutic index of two alkylating agents.提高两种烷化剂的治疗指数。
Br J Cancer. 1980 Sep;42(3):485-7. doi: 10.1038/bjc.1980.263.
4
Modulation of the toxicity and antitumour activity of alkylating drugs by steroids.类固醇对烷化剂药物毒性和抗肿瘤活性的调节作用。
Br J Cancer. 1982 Mar;45(3):413-20. doi: 10.1038/bjc.1982.69.
5
[Hematopoietic stimulation for enhanced bone marrow regeneration after chemotherapy (author's transl)].化疗后促进骨髓再生的造血刺激（作者译）
Klin Wochenschr. 1980 Mar 3;58(5):211-8. doi: 10.1007/BF01476966.
6
Intensive chemotherapy for solid tumours--current clinical applications.
Cancer Chemother Pharmacol. 1982;9(3):127-33. doi: 10.1007/BF00257740.
7
Treatment of advanced malignant melanoma with high-dose melphalan and autologous bone marrow transplantation.高剂量美法仑与自体骨髓移植治疗晚期恶性黑色素瘤。
Br J Cancer. 1983 Sep;48(3):329-34. doi: 10.1038/bjc.1983.196.
8
High dose melphalan with autologous bone marrow transplantation in the treatment of metastatic Ewing's sarcoma.大剂量美法仑联合自体骨髓移植治疗转移性尤因肉瘤。
Ir J Med Sci. 1983 Apr;152(4):160-4. doi: 10.1007/BF02960061.
9
Verapamil potentiation of melphalan cytotoxicity and cellular uptake in murine fibrosarcoma and bone marrow.维拉帕米增强美法仑对小鼠纤维肉瘤和骨髓的细胞毒性及细胞摄取。
Br J Cancer. 1985 Dec;52(6):813-22. doi: 10.1038/bjc.1985.264.
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Pharmacokinetics of high-dose melphalan in children and adults.高剂量美法仑在儿童和成人中的药代动力学。
Cancer Chemother Pharmacol. 1986;16(2):184-9. doi: 10.1007/BF00256174.