Millar J L, Hudspith B N, McElwain T J, Phelps T A
Br J Cancer. 1978 Jul;38(1):137-42. doi: 10.1038/bjc.1978.173.
The lethal effect of high-dose melphalan in mice could be offset by pretreatment with cyclophosphamide, cytosine arabinoside or low-dose melphalan. The reason for improved survival is unclear. Althoug animals given high-dose melphalan died with symptoms of gut death, in only one instance, that with low-dose melphalan itself, did pretreatment protect the intestinal epithelium as measured by the microcolony assay. A small enhancement in the recovery of the haemopoietic tissue in pretreated animals was noted, although this on its own is unlikely to explain the phenomenon. Experiments in tumour-bearing mice showed that pretreatment with cyclophosphamide did not reduce the toxicity of melphalan to the Lewis lung carcinoma.
用环磷酰胺、阿糖胞苷或低剂量美法仑预处理可抵消高剂量美法仑对小鼠的致死作用。存活率提高的原因尚不清楚。尽管给予高剂量美法仑的动物死于肠道坏死症状，但仅在一个实例中，即低剂量美法仑预处理本身，通过微集落试验测量，预处理保护了肠上皮。预处理动物的造血组织恢复略有增强，尽管仅此一点不太可能解释该现象。对荷瘤小鼠的实验表明，环磷酰胺预处理并未降低美法仑对刘易斯肺癌的毒性。
