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一种针对血型H1型和H2型结构的鼠单克隆抗体。

A murine monoclonal antibody against blood group H type-1 and -2 structures.

作者信息

Doinel C, Edelman L, Rouger P, LeBlanc J, Reviron J, Bach J F, Salmon C

出版信息

Immunology. 1983 Oct;50(2):215-21.

Abstract

A murine anti-H monoclonal antibody was produced. This antibody, called sp115, is an IgM that does not agglutinate classical Bombay. Sp115 may differentiate the two categories of H-deficient phenotypes. It detects H substance in both plasma and fresh saliva. Tissue antigen is found when using this antibody. The specificity of sp115 antibody was determined by adsorption with, and elution from synthetic oligosaccharide immunoadsorbents. Sp115 does not distinguish H type-1 and H type 2-structures.

摘要

制备了一种鼠抗-H单克隆抗体。这种名为sp115的抗体是一种IgM,不凝集典型的孟买型。Sp115可能区分两类H缺陷型表型。它能检测血浆和新鲜唾液中的H物质。使用该抗体时可发现组织抗原。sp115抗体的特异性通过与合成寡糖免疫吸附剂吸附及洗脱来确定。Sp115不能区分H1型和H2型结构。

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