合成A、B血型免疫吸附剂的实际应用

Practical application of synthetic A and B blood group immunoadsorbents.

作者信息

Crawford G, Adatia A, Naylor D H, Moore B P

出版信息

Rev Fr Transfus Immunohematol. 1981 Jun;24(3):281-7. doi: 10.1016/s0338-4535(81)80207-3.

Abstract

The effectiveness of synthetic blood group A and B immunoadsorbents in removing anti-A and anti-B from human sera was evaluated. The sera contained specific alloantibodies and were destined for use as diagnostic reagents. Both Synsorb-A(TM) and Synsorb-B(TM) removed all saline anti-A or anti-B activity from 20 sera tested. All trace of anti-A activity detectable by the indirect antiglobulin test was removed from only 20% of sera; anti-B with similar reactivity was removed from 66% of sera. Specific (wanted) alloantibody titres were reduced by synsorb-A in 60% of sera, but were unaffected by Synsorb-B. Despite these shortcomings, such immunoadsorbents are of value particularly when cells of appropriate phenotype are unavailable for absorptions.

摘要

评估了合成血型A和B免疫吸附剂从人血清中去除抗A和抗B的效果。这些血清含有特异性同种抗体，旨在用作诊断试剂。Synsorb - A(TM)和Synsorb - B(TM)都从20份测试血清中去除了所有盐水抗A或抗B活性。通过间接抗球蛋白试验可检测到的所有抗A活性痕迹仅从20%的血清中被去除；具有相似反应性的抗B从66%的血清中被去除。Synsorb - A使60%的血清中特异性（所需）同种抗体滴度降低，但Synsorb - B对其无影响。尽管存在这些缺点，但这种免疫吸附剂仍有价值，特别是在没有合适表型的细胞用于吸收时。