Letcher R L, Chien S, Pickering T G, Laragh J H
Hypertension. 1983 Sep-Oct;5(5):757-62. doi: 10.1161/01.hyp.5.5.757.
In patients with borderline hypertension, total peripheral resistance (TPR) is either elevated or abnormally related to cardiac output. Since blood viscosity is one determinant of TPR, we compared various components of blood viscosity in 25 patients with borderline hypertension and 25 normal subjects. Under all experimental blood flow conditions examined, blood viscosity directly correlated with systolic and diastolic blood pressure (p less than 0.05 or better) and was greater in the hypertensive than in normal subjects. Venous hematocrit and plasma viscosity were higher in the hypertensive patients. These latter rheologic abnormalities accounted for the increased blood viscosity at higher shear rates. At lower shear rates, increased red cell aggregation, primarily mediated by elevated fibrinogen concentration, accounted for the higher blood viscosity in the hypertensive subjects. We conclude that even relatively small elevations in arterial pressure are associated with increased viscous resistance of blood to flow, and that the increased blood viscosity is a consequence of increased hematocrit, plasma viscosity, and red cell aggregation.
在临界高血压患者中，总外周阻力（TPR）要么升高，要么与心输出量的关系异常。由于血液粘度是TPR的一个决定因素，我们比较了25例临界高血压患者和25例正常受试者的血液粘度各组分。在所有检测的实验血流条件下，血液粘度与收缩压和舒张压直接相关（P<0.05或更佳），且高血压患者的血液粘度高于正常受试者。高血压患者的静脉血细胞比容和血浆粘度较高。这些流变学异常导致了较高剪切率下血液粘度的增加。在较低剪切率下，主要由纤维蛋白原浓度升高介导的红细胞聚集增加，导致高血压受试者的血液粘度较高。我们得出结论，即使动脉压相对较小的升高也与血液流动的粘性阻力增加有关，并且血液粘度的增加是血细胞比容、血浆粘度和红细胞聚集增加的结果。
