Azadegan A A, Schell R F, LeFrock J L
Infect Immun. 1983 Oct;42(1):42-7. doi: 10.1128/iai.42.1.42-47.1983.
Pooled serum from hamsters immune to syphilitic infection conferred complete protection on recipient hamsters challenged with Treponema pallidum subsp. endemicum. Cutaneous lesions did not develop, and the recipients' lymph nodes weighed less than those of controls and contained no treponemes. Treponemicidal activity in the pooled immune serum was relatively high. When treponemes were incubated in immune serum and complement and the suspension was then inoculated into hamsters, recipients developed neither lesions nor enlarged lymph nodes teeming with treponemes. With hamsters already infected for several weeks, however, immune serum failed to impair or influence the progression of syphilis. Treponemes were eliminated only when immune serum was administered within a short time of syphilitic infection. These results demonstrate that hamsters develop an effective serum-mediated treponemicidal response, but this response is not sufficient to eliminate treponemes at the primary foci of infection.
来自免疫于梅毒感染的仓鼠的混合血清，能为受到地方亚种梅毒螺旋体攻击的受体仓鼠提供完全保护。皮肤损伤未出现，受体仓鼠的淋巴结重量比对照组轻，且不含梅毒螺旋体。混合免疫血清中的杀梅毒螺旋体活性相对较高。当将梅毒螺旋体在免疫血清和补体中孵育，然后将悬浮液接种到仓鼠体内时，受体仓鼠既未出现损伤，也未出现充满梅毒螺旋体的肿大淋巴结。然而，对于已经感染数周的仓鼠，免疫血清未能损害或影响梅毒的进展。只有在梅毒感染后短时间内给予免疫血清，梅毒螺旋体才会被清除。这些结果表明，仓鼠会产生有效的血清介导的杀梅毒螺旋体反应，但这种反应不足以消除感染原发灶处的梅毒螺旋体。
