Schell R F, LeFrock J L, Chan J K, Bagasra O
Infect Immun. 1980 Jun;28(3):909-13. doi: 10.1128/iai.28.3.909-913.1980.
The inbred LSH/Se LAK strain of hamster can be infected with Treponema pallidum Bosnia A, the causative agent of endemic syphilis. When infected, this strain consistently produced extensive chronic skin lesions that persisted for 6 to 9 months, even in the presence of peak antitreponemal antibody titers. The lymph nodes increased in weight and contained measurable numbers of treponemes. This infection also gave the hamster cross-immunity to T. pallidum Nichols and Treponema pertenue, the causative agents of venereal syphilis and frambesia, respectively. LSH hamsters are thus an excellent model to study the immune response mechanisms to syphilitic infection.
近交系LSH/Se仓鼠品系可感染地方性梅毒的病原体苍白密螺旋体波斯尼亚A亚种。感染后，该品系始终会产生广泛的慢性皮肤病变，持续6至9个月，即使在抗梅毒螺旋体抗体滴度达到峰值时也是如此。淋巴结重量增加，且含有可检测数量的梅毒螺旋体。这种感染还使仓鼠对分别导致性病梅毒和雅司病的苍白密螺旋体Nichols亚种和 pertenue亚种具有交叉免疫力。因此，LSH仓鼠是研究梅毒感染免疫反应机制的优秀模型。
