Schell R F, Azadegan A A, Nitskansky S G, LeFrock J L
Infect Immun. 1982 Aug;37(2):617-21. doi: 10.1128/iai.37.2.617-621.1982.
Hamsters infected with Treponema pallidum Nichols (venereal syphilis), T. pallidum Bosnia A (endemic syphilis), or T. pertenue (frambesia, or yaws) developed substantial resistance to homologous reinfection. Hamsters infected for 10 weeks developed no lesions, and their lymph nodes contained fewer treponemes after reinfection with the same strain. The degree of cross-resistance among the treponemes correlated well with pathological changes occurring in infected hamsters and with the persistence of treponemal antigen during primary infection. Only hamsters infected with T. pallidum Bosnia A developed substantial resistance to heterologous reinfection. These animals also had extensive chronic skin lesions and lymph nodes containing measurable numbers of treponemes. Frambesial hamsters had less extensive lesions and were resistant to T. pallidum Nichols and, to a lesser extent, to T. pallidum Bosnia A. Hamsters infected with T. pallidum Nichols developed no cutaneous lesions and were resistant only to reinfection with T. pertenue. Confirmation of these results was obtained in normal hamsters infused with syphilitic (Nichols or Bosnia A) or frambesial immune cells and challenged with homologous or heterologous treponemes.
感染梅毒螺旋体Nichols株（性病性梅毒）、梅毒螺旋体Bosnia A株（地方性梅毒）或雅司螺旋体（雅司病）的仓鼠对同源再感染产生了显著抗性。感染10周的仓鼠再用同一菌株感染后未出现病变，其淋巴结中的梅毒螺旋体数量减少。这些螺旋体之间的交叉抗性程度与感染仓鼠中出现的病理变化以及初次感染期间梅毒螺旋体抗原的持续存在密切相关。只有感染梅毒螺旋体Bosnia A株的仓鼠对异源再感染产生了显著抗性。这些动物还患有广泛的慢性皮肤病变，其淋巴结中含有可检测数量的梅毒螺旋体。雅司病仓鼠的病变范围较小，对梅毒螺旋体Nichols株有抗性，对梅毒螺旋体Bosnia A株的抗性较弱。感染梅毒螺旋体Nichols株的仓鼠未出现皮肤病变，仅对雅司螺旋体再感染有抗性。将梅毒（Nichols株或Bosnia A株）或雅司病免疫细胞注入正常仓鼠，并对其进行同源或异源螺旋体攻击，证实了这些结果。
